Biphasic model of sexual dysfunction

Orgasmic disorder is defined as the persistent or recurrent inability to achieve orgasm with sexual stimulation and arousal. Similarly, nonsignificant difference in the composite Male Sexual Health Questionnaire-Ejaculatory Dysfunction-Short Form score was reported at week among androgen-deficient DE patients. This experimental model involves the dissection, harvesting, isolation and conservation of the human corpus cavernosum, cavernous artery and urethra under ideal conditions along with the accompanying physio-pharmacological studies. The band intensity was measured using quantity one software program. These studies suggest that estrogens modulate genital hemodynamics and are critical for maintaining tissue structural integrity. The two binding sites have been used to explain the activation and substrate inhibition and biphasic saturation curves for the cytochrome P enzymes [ 52 ].
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Oxidative Medicine and Cellular Longevity

The glans of the clitoris forms a cap that sits on the ends of the corporal bodies and is richly innervated by sensory nerve endings [ 5 ]. Some of these stages may be absent during some sexual encounters, or out of sequence in others. The body of the clitoris is surrounded by tunica albuginea and consists of two paired corpora cavernosa composed of trabecular smooth muscle and lacunar sinusoids. The present paper presents a comprehensive model for harvesting human corpus cavernosum tissues and for carrying out smooth muscle relaxation experiments in vivo. These studies have shown that sexual arousal and frequency of coitus in the female decreases with increasing age. Biphasic effects of anandamide on behavioural responses:
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Experimental model of human corpus cavernosum smooth muscle relaxation

Role of nitric oxide in the relaxation elicited by sildenafil in penile resistance arteries. A retrospective study was undertaken of 16 patients treated with adjunctive buspirone in the context of sexual dysfunction associated with the use of SSRls Published online Jul After electrophoresis, proteins were transferred to nitrocellulose membranes using a semidry trans-blotter. Management of Sexual Inadequacies. The spinothalamic pathway contains myelinated fibers that end in the posterolateral nucleus of the thalamus, from which the signals are relayed to the medial thalamus.
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A VIP receptor antagonist has been shown to significantly increase the relaxation response to VIP while having little effect on EFS-induced relaxation of the vaginal tissue [ 40 ]. Conclusions The psychosocial and relationship aspects of female sexuality have been extensively investigated. Intracavernous Pharmacotherapy for erectile dysfunction. Early postoperative pelvic-floor biofeedback improves erectile function in men undergoing radical prostatectomy: Jensen studied the sexual function of 80 diabetic women and 40 non-diabetic women [ 58 ]. It is known that PDE-5 inhibitors have revolutionized the treatment of erectile dysfunction and changed the life of million people worldwide. However, studies concerning the anatomy, physiology and pathophysiology of female sexual function and dysfunction are limited.
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